Dear (Hiring Manager)
I am seeking the opportunity to apply myself to the vacant (job’s name) position to enable me capitalize on my professional experience whilst allowing me to progress in my career.I now desire a fresh challenge and the possibility of progression, to enable me to fulfill my career objectives and build upon the highly relevant skills I have already attained.

As my CV reflects, (talk about your work experience)

I believe I am a suitable candidate for the position in view of my professional experience. I hope therefore, that on consideration of my CV, you will be persuaded of my potential to perform well and make a real contribution as a member of your organization. In the meantime I am looking forward to hearing from you at your earliest convenience.
Sincerely,
Your name