Che si dice zio? = what's up dude? (zio means uncle, and is an equivalent to dude,bro, mate....)
Hey bello com'è? = litteraly means "hey "handsome" what's up? ( we say it naturally, even if it could sounds "odd" to english native speaker; we doesn't mean litteraly as an adjective; we just say "bello" like you say "bro" etc... )
We also say "man" like an italian word:
Hey man com'è?
An other good one:
Wee zio tutto a posto?
An other "dude" word it's used in certain parts of Italy is "Biondo".
It means "blonde hair" and we use like your "bro, dude, mate,..."
(even if you aren't blonde haired xD xD xD )
Heyy biondo! Com'è?