Just reply with your response, what you think about what they're saying. Usually it's just the pitch of what your saying and the facial expressions that you portray that will determine your emotion.
Like if you laugh while saying something it's usually that they've said something wrong, funny or you don't know what to say.
If you are high pitch and say it kind of fast, you're happy or excited.
Friend: I saw *someone* today.
You: Really :)
If you extend your answer. It's almost to say that you disagree or are unsure of what they're saying.
Friend: Do you know what the next question is?
You: Oh, I~~'m not to sure, sorry.
You can pretty much say anything in many ways and they can all mean different things. Try to match your facial expressions with what you intend to say.