Hi Jessica,
Homie tends to be more American slang and not widely used in England so you would be unlikely to hear it used here. As I understand it though it does tend to be used mainly between males, perhaps "homegirl" would be more appropriate for females, however as with homie this is not used in England.
To correct your question;
I have a question. Can I use "homie" if I'm talking to a girl, or woman? What I mean is, I know I can call a close friend "homie". I just want to know if I can call one of my girlfriends homie?
Thanks a lot.
I know my English is not the best but I'd appreciate it if besides answering my question, you could correct what I wrote.