There are some combinations of sounds that occur in English that are genuinely difficult to pronounce carefully--they require a lot of quick tongue movement. They are often blurred in rapid, casual, or sloppy speech.
These are all just examples of bad diction or mispronunciation:
In "Hundred," the d-r transition is difficult, so it comes out as "hunnerd" or "hunn'd."
"Library" is another--the b-r is difficult, and often the word is pronounced "Liberry."
"February" is another; it is very common, but simply incorrect, to say "Febuary." It is so common that it is often misspelled "Febuary." (Here, there is a tendency to assume it should rhyme with "January.")
"Nuclear" is famously difficult; former U.S. President George W. Bush and many, many, many other mispronounce as "Nucular."
"Ophthalmogist" is difficult--all of the words with "phth" are difficult--and is frequently mispronounced and misspelled "Opthalmologist."
"Naturally" becomes "Natcherly."