They are the same in some, but not all, situations.
1. When you are making a suggestion, they are interchangeable:
"What should we have for dinner?" "How about pizza? / What about pizza?"
2. When you want to say 'Hold on a moment, haven't you forgotten..?' only 'What about?' works.
"I've got a tie for Dad, some perfume for Mum, and toys for the kids."
"Hey, what about me? Don't I get a present?'