Generally interchangeable.
高兴 is more general and can be used to describe a wide range of happy or positive emotions, while 开心 is more specifically used to describe a feeling of joy or delight. In general, both words can be used interchangeably to describe happiness, but 开心 tends to be used in more informal or   contexts, while 高兴 is more commonly used in formal or polite settings.
 

Difference between A and B in Chinese with Shanmei

高兴VS开心 differences

Il corvo sta tranquillamente mangiando un pezzo di formaggio quando la volpe lo vede e pensa ad un modo per ingannarlo e prendergli il cibo.

Vittorio per Voi

Il corvo e la volpe

En este episodio quiero explicar por qué hablamos tan diferente en cada país de Latinoamérica? Cómo un sólo idioma puede variar tanto? Bueno, hay motivos socio-antropológicos e históricos que explican este fenómeno. 
I want to explain why we speak so differently in each Latin American country. How can a single language vary so much? Well, there are socio-anthropological and historical reasons that explain this phenomenon.

*La mayoría del podcast está en español, con unas pequeñas aclaraciones cruciales en inglés. 
The majority of the podcast is in Spanish, with a few crucial clarifications in English.*

Perdónenme si me equivoco un poco al hablar, es que a veces hablo muy rápido. Si estoy hablando muy rápido, diganmelo en un mensaje.
Sorry if my English is not perfect. I did my best to give you the essential information.

Música de Intro: Ñasaindy Syry (idioma guaraní). Manantial Lunar (en español)
Pueden oirla aquí https://youtu.be/ipODqykklYU 
You can hear the intro music in the link above. It's beautiful, from a tourist spot. 

If you want to learn more Spanish language and regionalism, especially the Paraguayan one, schedule a trial class and let's talk! 

Rohayhudcast! Paraguayan spanish!

Episodio 1: Por qué los latinos hablan el español tan diferente entre sí? Why do Latin people speak so differently?

Buy Me a "coffee"☕️: https://ko-fi.com/cestinasdavidem

Hudba: Jingle Punks Good Starts CC

Čeština s Davidem

Vtipy 01

In this short episode, I discuss a few interesting studies about language learning that you might enjoy. :)

Learning Strategies for Success with Tyler Teacher

3 *Fun* Facts about Learning Languages (Episode 5)

陕西汉中有一道传统美食，梆梆面。There is a traditional delicacy in Hanzhong, Shaanxi province, Bang-bang noodle.
它选用麦子磨成的上等面粉精制而成。It is made of fine flour ground from wheat.
在古代、人们一般在早上三、四点钟时、就要在街边售卖，而且在制作的时候、伴有梆梆的敲击声，所以大家就称它为“梆梆面”。In ancient times, it was usually sell on the street at three or four o 'clock in the morning, and it was made with a bang-bang sound, so people called it "bang-bang noodle".
因此，这个面引出了一个特别有意思的象声字，如下图所示：Interestingly, the noodles have created a distinctive phonetic character, as shown below:


新鲜事儿（Anecdote）

梆梆面

Hey everyone! Today’s topic is beauty! How picky are you about your skincare? I wonder if it’s different around the world. I’d love to hear what you all think!
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Moekoの日本語ベラベラtime

Moekoの日本語ベラベラtimeEpi34: 美容ってどこまでする？【Japanese Podcast: listening practice】

In my country, FOOD is an important part of our culture and idiosyncracy. So, in this episode, I'll talk about the two most traditional sweets dishes in Argentina and a drink you probably never heard about. Are you ready?

Your Spanish Journey

Customs and traditions from Argentina and Latin America. Today: The three most popular dishes - Part 2 (sweets and drinks)

Sweden has launched a new law that allows grandparents to get paid parental leave while taking care of their grandchildren for up to three months of a child's first year.

