What do these words mean in the sentence below?

Once a DNA adduct is formed, a major *determinant* of its *persistence* depends on the ability of the cell to repair the altered DNA.

My opinion --

Determinant= reason
Persistence= existence?

Question

What do these words mean in the sentence below?

Once a DNA adduct is formed, a major *determinant* of its *persistence* depends on the ability of the cell to repair the altered DNA.

My opinion --

Determinant= reason
Persistence= existence?

Answer

It might be easier to reword the sentence slightly:

"a major part of  (the adduct) continuing to exist will be if the cell can or cannot repair the DNA."

Determinant = event or thing that decides something
persistence = continues to be for a long time

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