How do you say "what's wrong?" in Korean???
i know how to say "잘지냈어요?" as in " Have you been well?"
but what do i say if someone is sad?

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I'm sorry I missed the part where you say if someone is sad so to be literal and direct to your question. " why are you sad,  wae seulpeoh ". Sorry for spelling I may be off.

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u can say "무슨 일이 있어요" (what's matter with u/ what's up)

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I do not know if my spelling will be good but waegeulae meaning what's up or museun il-iya meaning what's going on. I hope this helps you.