You can never say 'most of people'. You can only say 'most of' before a pronoun.

If you are talking about a large or general group then you need to use( most people ): Most people know how to write a letter. But, if you are talking about a smaller or more specific group then you need to use ( most of people ) Most of people in my neighborhood are well educated.

thank you, Nancy

Or as in Fahad's example sentence, you would have to say "Most of the people in my neighborhood are well-educated."

Yes, I agree with Jmat, you can never say "most of people." Just "most people" OR "most of them."