They are very similar. The only difference is a slight shade of meaning.
"I've never thought about that" probably refers general open-ended area of thought. For example, in answer to a question like, "What will you do when you retire?" "What do you suppose Mars is like."
"I've never thought of that" more likely is in response to a specific suggestion or idea. For example, "Did you know that by you could reduce your electric bill by going to bed earlier." Sorry couldn't think of a better example.