What does "lose one's marbles with her remote control" means? In the latest Big Bang( S05 E09), Bernadette remark Sheldon like "Oh, it's just like my grandma with her parrot. And after she lost her marbles with her remote control." What does "lose one's marbles with her remote control" means? What logicality between the lines? "it's just like my grandma with her parrot. And after she lost her marbles with her remote control." What does the "and" mean here?