I want to impove English Hi, friends, if you want to impove your English, let's study together. If your mother language is English, you want to impove Chinese, let's study each other.We can Skype.

Studies on Protective Immune Mechanisms in Chickens Using Transgenic Eimeria as a Pathogen Model There are two basic questions to be addressed in the development of vaccines, one being WHICH ANTIGENS ARE PROTECTIVE ANTIGENS FROM A PATHOGEN, the other THE MECHANISM CONTROLLING THE PRESENTATION OF A PROTECTIVE ANTIGEN AND THE ELICITATION OF PROTECTIVE IMMUNITY IN A HOST. Our recent studies demonstrate that foreign antigens expressed by transgenic Eimeria induced potent immune responses in chickens. Based on the current progress in immunology and our findings, we will address the second question mentioned above by the usage of transgenic Eimeria as a pathogen model. We will construct different transgenic Eimeria strains expressing protective proteins from avian influenza virus, ligands for immunoreceptors, and cytokines and employ heterologous prime-boost vaccination regimes to test two hypotheses proposed in this proposal, the first being that the induction of protective immunity be regulated by combination of pathogen factors (antigen characters, locations, dose and duration of antigens), host factors (binding of its immunoreceptors by ligands and cytokine milieu) as well as vaccination regimes; the second being that ligand (antigen to be cross-presented) binding to its pattern recognition receptor on the professional antigen-presenting cells together with its cytokine milieu decide which exogenous antigen to be cross-presented to MHC I pathway. The most convincing and generalizable of findings from this study will be the elucidation of the mechanism controlling the induction of protective immunity and will provide a new and useful protective immune correlate of protection for the state-of-the-art vaccine development in chickens and other livestock.

First notebook entry: Introducing myself Now I want to improve my english, especially speaking and listening. The American speak too fast that I cannot understand them at all. So I need to study authentic english, then I find italk. I hope that I can chat with some english teachers on italk to improve my english.