Related to buildings? A home is the place where a person lives. A house is a general term for a building which people live in.
"I bought a book about building houses. I will read it when I get home"
This is the basic difference and the most common. You may see house and home being use in other ways. For example,
House isn't just a noun...
It can be a noun: "a house made of wood", "a house of prayer", and as a noun modifier "house prices"
It can be an adjective: "the house band", "the house red (wine)", "the house rules"
It can be a verb: "the London Museum houses a wonderful collection of artifacts"
It can be a noun: "I left home at 18", "I was five minutes from home", and as a noun modifier "home ownership"
It can be an adjective: "the home team", "their first home game of the year"
It can be an adverb: ""what time did he get home last night?"
It can be a verb: "home in on" (i.e. home in on a target)
House is a noun.
Home can be a noun or an adverb. For example, "go home" is correct, but "go to home" is incorrect (after "go", it's an adverb).