Related to buildings? A home is the place where a person lives. A house is a general term for a building which people live in.
    For example:

                "I bought a book about building houses. I will read it when I get home"

This is the basic difference and the most common. You may see house and home being use in other ways. For example,

House isn't just a noun...

It can be a noun:  "a house made of wood", "a house of prayer", and as a noun modifier "house prices"

It can be an adjective: "the house band", "the house red (wine)", "the house rules"

It can be a verb: "the London Museum houses a wonderful collection of artifacts"

Home :

It can be a noun: "I left home at 18", "I was five minutes from home",  and as a noun modifier "home ownership"

It can be an adjective: "the home team", "their first home game of the year"

It can be an adverb: ""what time did he get home last night?"

It can be a verb: "home in on" (i.e. home in on a target)

House is a noun.

Home can be a noun or an adverb.  For example, "go home" is correct, but "go to home" is incorrect (after "go", it's an adverb).