-.He is not in his office.
-She is not a good football player.
-I am not a good student.
-We are not old friends.
-She is not absent from class today.
-She is in class today. Removes confusion over is it a double negative or not? it is not
-Are they brothers? 0r 'are those two brothers' for two people only.
-Are he and Mary good students?
-Is he a happy child?
-Is she an honest woman?
-Are they friends?
-My family is at home.
-I'm playing computer games right now.
-He is listening to music.
-Her name is Alice and she is my best friend.
-They are the best of friends.
-They are good friends.
-Are he and Mary good students?
seems grammatically ok but doesn't sound good it is awkward
-Are John and Mary good friends.
if you do not know one persons name it is
-Are they good friends