It depends on the cotext.

In the majority of the time, "Comme ça" is to show an object, an aspect of something. For example, "You can't say something like that" You'll translate it into "Tu ne peux pas dire des choses comme ça"

Sometimes, it can be a transition word in a sentence, but it's very informal. 

Example: "Tu devrais prendre ta voiture, comme ça tu seras à la banque plus rapidement" Here you can't translate by "like that" you will say "You should take your car, by this way (not sur about this part of translation), you'll be at the bank more quickly". 

it would be easier with an exemple (in english or in french)

comme ci, comme ca= like this, like that.