In the United States, the National Football League (NFL) is currently holding its annual playoffs which lead to the Super Bowl where the NFL champion will be crowned. Tim Tebow is the quarterback of the Denver Broncos. He is a devout Christian who openly prays on the football field many times during a game. It is a source of controversy, especially since many think he is not that good at his job.
Last weekend, the Denver Broncos were defeated by the New England Patriots by the score of 45 to 10 (45-10) which is an overwhelming defeat. The Patriots set records in the first half of the game. The "like 45-10" in your quote refers to this outcome and implies it was the work of God.