They both mean almost the same
"Disculpe" is a formal way to say excuse me.. to your professors, old people, people you barely know o people you dont know at all.
"Disculpame" is more informal that the first one.. to your friends, people of your same age etc..
"Perdón " is the almost same as pardon but not in all contexts
you can use it, when u didnt hear something, u say: Perdón, qué dijo? but thats too polite.
perdón is also deeper than disculpe or disculpa.
if u hurt to someone u ask for their forgive by saying : Perdón
Perdóname is more informal: To ur family, to ur god, to someone who you love
u may hear perdóname in love songs.
Sorry for my english i still learning it