If he/she is healthy and not too ugly, I'll say nothing because he/she had not the choice.
But, if it's a sort of sickness or deformation I advice him/her to go and see the doctor maybe an esthetical surgery will make a difference. I saw many examples in TV and even in real life, how such operations made major improvements on those peoples' life.
I wonder how will be the effect on handicapped people, who lost hope in life?!