All in all / Generally/, you can use these expressions whenever you want to mean you are worried.
synonyms: generally, in general, generally speaking, altogether, all in all, on balance, on average, for the most part, mostly, in the main, on the whole, largely, by and large, to a large extent, to a great degree; predominantly, mainly, chiefly, as a rule, principally, basically, substantially . Some better than others as a 100% replacement of the word (depending on context)