Just an addition to what has been already said. There is an idiomatic expression "как это?" that roughly means "what is it?", and Russians use it a lot, although it might seem wrong. Thus, the answer for your question is yes, sometimes you can.
-Я занимаюсь логистикой = "I do logistics"
-Логистикой? Как это? = Logistics? What does that mean? (I haven't heard this word before)
-Ты умеешь решать дифференциальные уравнения? = Do you know how to solve differential equations?
-Как это? = (No, I've never done it and I even don't know what this is)
But if you point at something and asking what it is, you only can ask "что это?" Hope this helps.