No, not usually. Native English speakers normally pronounce all three consonants audibly. However, in my personal opinion, if you are really having trouble with it, and your goal is simply fluency in conversational English, you can just pronounce it as "s" and people will understand. Try to get it right someday, but it doesn't need to be a high priority.
In one of Stephen King's novels, a character is taught to say "He thrusts his fists against the posts and still insists he sees the ghosts" to conquer his stuttering. That is, the "-sts" sound is difficult for him. I am going to see how well I can do. I am going to speak that phrase, and follow it with two lines from George Orwell's "Animal Farm:" "Beasts of England, Beasts of Ireland, Beasts of every land and clime." I am not going to practice, I am going to read it at full conversational speed, and whatever I record the first time is what I will post, no re-dos.
I see someone has posted a YouTube video of a rock version of "Beasts of England." I can hear the -sts clearly, both as sung by the lead singer and the chorus.
Actually I don't understand why it _isn't_ difficult for most native speakers. My guess is that it is because there are literally thousands of English words ending in "-st", so we get a lot of practice pronouncing "-st"--and we need the plurals often enough that we get to practice "-sts."