Single word break·through = we have made a major breakthrough in DNA research
noun: breakthrough; plural noun: breakthroughs; noun: break-through; plural noun: break-throughs
a sudden, dramatic, and important discovery or development.
"we have made a major breakthrough in DNA research"
synonyms: advance, development, step forward, success, improvement;
Two words [break through something] to force your way through something that is stopping you from moving forward
A group of young demonstrators attempted to break through police lines.