"settle over", "film of great weight" meaning.
I brought the original sentence below from "Do androids dream of electric sheep?"
she ceased to move, as the instinctive, omnipresent film of great weight, of an almost absolute inertia, settled over her.
Here are my guesses
1. film of great weight = A film that is really heavy or A film that is really important.
2. settle over = settle down or fall down or drop etc..