Usually we say “any questions” in the plural, but that’s only because we would expect there to be more than just one question. If, however, “question” means “doubt”, then yes, it would be common enough to use the singular. “Is there any question that Mandarin has more speakers than any other language?” (Answer: No, there is no question at all.)
In fact, we can use “any” in the singular any time that we suspect the answer is singular: “Is there any reason that we should not proceed with our plans?” (The speaker expects that there is no reason, or at most one reason. Answer: “No, there isn’t any reason.” (= There is no reason.)