It means that the person talking is rejecting something and usually telling the person that they should leave.
Generally a rejection of some kind. Not polite language. Not to be used in polite company.
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A: You should not drop litter here.
B: Go screw yourself. I'll do what I want.
October 19, 2019
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It is a very offensive term. You can google it for an exact explanation.
October 19, 2019
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