Or, one can subscribe to Philosophical Dualism, and follow the idea that a Mind/Body combination seems to have the best explanation for everything in human experience.
The Classical Dualist position, which is generally the philosophy endorsed by most philosophers historically, and has had strong arguments in the form of several Proofs by Logic as its basis for claiming the greater "explanatory power".
The Ontological Naturalist Philosophy, as a Monism by the has no logical proofs for anything to substantiate it.
When someone tries to "explain" everything in strictly Monist terms, which is to say that
Matter, Energy, Space and Time can "explain" everything mankind thinks and feels, obvious difficulties develop.
So many Transcendental Conceptions that people all over the world adhere to, such as Good & Evil and personal experiences, combined with basic beliefs we all hold to such as the idea that each person is a uniquely individual SELF, are deeply embedded in all of the world's cultures.
On the basis of a disciplined Science however, no SELF has ever been discovered in the physical anatomy of Homo Sapiens Sapiens. Therefore, the idea that Brain enables explanations for all of human experience, on the basis of Matter, Energy, Space and Time, simply fails. Abstractions do exist, and Mind seems to be the best explanation.
Skeptics object to this. Mind, as part of the Dualist Worldview, is, owing to its immaterial and non-physical identity, a reference also to Transcendental Conceptions such as Soul, Spirit, and God.