It could have different meanings,since you don't have a certain context ,here are the different possibilites : - 'handoff' in American Football is a play in which one player hands the ball to a teammate. - In a cellular telephone network, " handoff " is the transition for any given user of signal transmission from one base station to a geographically adjacent base station as the user moves around. - Another general meaning refers to the act or an instance of passing something or the control of it from one person or agency to another. "The handoff of the operation from one control unit to another." In aviation specifically the term means the condition or period in which control or surveillance of an aircraft is transferred from one control center to another. - handS-off (with an 's') ,when it is about a machine or a device ,the adjective means without need of manual operation.

American football - in which one player hands the ball to a teammate. In communication it would refer to passing on data from one channel to another. (can you please quote its context?)