I filled the prescription. Is it CORRECT to say?
I often hear English native speakers say "I filled the prescription (four days ago)."
Is it really natural to say? According to the dictionary, 'fill a prescription' appears to mean 'make up a medicine'. Since in general, the pharmacist is the one who fills the prescription, not you. So, I think the sentence should be "I had the prescription filled." or "I had the pharmacist fill the prescription." What do you think?

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It's not correct, but it's very natural.

Native speakers use incorrect English all time. We use slang, jargon, and regional speech patterns. We misspeak, we make mistakes, and, sometimes, we are just plain lazy.

(Now, if you'll excuse me, the pharmacy closes in ten minutes and I gotta go fill a prescription. ;)

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You may hear American English speakers say it - as the others suggest, because they are lazy or ignorant of how to say it properly. ;p I don't think you will hear English people say that though.

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It's perfectly natural to say. It's not literal. It means we 'had it filled.'

You say that you hear native speakers say it. Why do you think that a native speaker would make such a mistake and not realize it?