You can use a colon to introduce an item (or items), or to explain the first part of the sentence. There are two parts to this sentence: 1. Who would you rather spend your evening with, and 2. me, or a pickled toad? 1. is an independent clause, because it's a complete sentence on its own. 2. is a dependent clause, because it's not a complete sentence on its own. Yes, you can use a comma between an independent clause and a dependent clause. You can never use a comma between two independent clauses. This is called a 'comma splice.' However, I think a colon is better here, because it makes the sentence clearer and easier to read. Who would you rather spend your evening with: me or a pickled toad?

"With"后面一定要加逗号或者冒号。还有，你既然只有两个选择，"me"后面不要逗号。 "Who would you rather spend your evening with: me or a pickled toad?"

That's right - the comma would go before me. Who would you rather spend your evening with, me or a pickled toad?