Acute myeloid leukemia AML AML, the most common form of acute leukemia, is a rapidly fatal cancer potentially causing death in a short period of time. Recently, a lot of research work revealed that nanomaterials acting as carrier or as drug obtained marked results on AML treatment. In this review, we are going to specially summarize these hopeful works and we believe this work will be of great interests, and particularly to researchers working on AML treatment. Our research team is working on developing multifunction nanomedicine which will overcome barriers of traditional anti-tumor drugs, and we are confident that we can summarize the latest research works of AML treatment based on nanomaterial well.