You would use 不. You're referring to the reply to: "How are you doing?", right?
٢١ سبتمبر ٢٠١٢
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You would say "不太好". If you wanted to lighten the mood , you'd still use "不", but it would be changed to "不错", which means "not bad". Using "没" is different. It's more like "haven't".