The word "therefore" is used when you have evidence and you want to make a statement based on that evidence. Example: My business did not make any money last year, therefore I will have to close it down. "Therefore" is fairly formal, an informal substitute is the word "so". My business did not make any money last year, so I will have to close it down. I hope this helps :)

Therefore is fairly formal word. We don't tend to use it much in everyday conversation or informal writing. In less formal situations you'd just say 'so' .

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