Despite having different cultures, both Western and Eastern readers all resist the depiction of a Geisha in Memoirs of a Geisha.

1. Viewers in the East and West (both/all) resist Memoirs of a Geisha’s depiction of Geisha regardless of different cultural positions. 2. Regardless of different cultural positions, Eastern and Western people resist the depiction of Geisha in Memoirs of a Geisha. When you say directions they usually follow order: North, South, East, West

The second is much better. It clearer what the meaning of the sentence is.

Regardless of different cultures, Western and Eastern viewers resist the depiction of a/the Geisha in Memoirs of a Geisha.