Yes, you can say that the room is emty in the context of no people being in it

Here (in NZ) one would, with no further context, take 'a room is empty' to mean there is nothing in it, no furniture.

see if a 'vacant room' works.

Most often, the phrase "the room is empty" means that there is no one in the room. However, depending on the context, it could also mean there is nothing in the room house (furniture, personal belongings, etc.). For example, if someone were moving out of a house, they could say the house is empty, and it could mean that the house has nothing in it.

Thank you guys for answering my question. Really appreciate it!!