That's a tough one, but I think the meaning is this: When you are too scared to talk, people won't like you. But you can't make yourself liked, because you are too scared to talk. So, you are in an unfortunate situation where there is no solution to your problem. "Irony" is a difficult word with many meanings. An example that is relevant here: "It is ironic that the one person who could help him is the one person he did not want to ask for help from." This sense of "irony" is that there is some sort of cruel or unhappy coincidence that makes something difficult or impossible. "Is not lost on me either" means that you understand something. If something is "lost on you," it means you do not understand it.