Yes... if you want to wake up the next morning cursing the day you were born =p
Sometimes, you could put some tequila on the bottom of a large glass full of beer, with the "shot" (i mean, the little glass that you use to drink tequila) and then drink it. O_O hahahaha... but, usually, no one wants to do that, so it's normally used as a 'consequence' when you are playing something with your friends... like JENGA ! Whoever makes the tower fall, drinks it !!!