An area is simply a a certain amount of land. For example, the area of my far is 200 hectares. A region is also an area which is is different to other areas and is given a special name. For example, the southern region of China is GZ and that is different to the northern region of China which could be, say, Shandong or another region.

drsuess, is right. A region is a distinct geographical place.

I can tell you only what I would use these 2 words in. If it is a large area, than it is a region. Example: I live in the Northwest region of the United States. An area I would usually use it for smaller places. Example: This area of this room is used for books. I would never say This region of this room is used for books. So for myself, I use area for smaller places and for larger places I use region. I hope this helps.

Area is a particular geographical region of indefinite boundary (usually serving some special purpose or distinguished by its people or culture or geography) Region is the extended spatial location of something Field is a piece of land cleared of trees and usually enclosed cowboy...

to throw a curve ball in... how about a zone? a domain? Technically for common speaking, an area is bounded by man made borders whereas a region is an extent shared by common characteristics whether it is man-made or not. Usually a region is much larger than an area. However in mathematics, all these terms have specific meanings.