Parkinson's disease Parkinson's disease (PD) is the second most common neurodegenerative disease around the world. The older you are, the more possible you have PD. Typical patients with PD show motor syptoms like tremor, rigidity and bradykinesia (slowness of movement). The majority of PD cases are sporadic, although we have konwn some factors are related to the risk of PD, such as genetic factors and certain toxins. Except motor symptoms, patients often have non-motor sympotms, like sleep disturbances, depression and variety. Although many people suffer from PD, there is no treatment for curing it or slow down its progression. Current we just have symptomatic treatment, like dopaminergic replacement and surgery.