I want to know if I can say "Relax from the deep of your heart".
Thanks for help!

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@Nanren888 thank you so much! got that: I can say I thank you from the bottom of my heart.

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Relax deeply, completely, 
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No "heart" involved in relaxing in English, that I know of.
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>>So can I say: I thank you from the bottom of my heart?
Yes, you can say that. (I took the extra full stop out :) )

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@Howard, sorry for troubling you. So can I say: I thank you from the bottom of my heart.?

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@Howard, thanks for the help!  I understood. So I should say "relax completely".

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"From the bottom of my heart" is an expression of how genuinely and sincerely we want to show our gratitude. We don't use it with a command like "Relax". Perhaps you just want to say "Relax completely" or "Let go, unwind"?