No mister needed sister 😁
I'll never make a Shakespeare. But seriously, it's neither necessary nor expected in a forum where English and western culture prevail.
I understand your concern, though. We have the same thing here in India. We address those who are older to us or higher in social status using the suffix -ji, which is gender neutral and identical to the Japanese honorific san.
It goes with everything. A name (<em>somji</em>), a surname (<em>bhattaji</em>), a relative (<em>mataji</em> - mother, <em>pitaji</em> - father, <em>nanaji</em> - mother's father = grandpa, <em>chachiji</em> - father's brother's wife = aunt). It can also be used for elder brother (bhaiyaji) or elder sister (didiji) but isn't in practice. The base words bhaiya and didi are used instead.