These words are very close synonyms. "Whole" comes from "unhurt", and means a single object that has not been subdivided. e.g. I ate the whole pie by myself. I’m so full right now. "Entire" comes from "complete", and means no part has been left out. e.g. I spent the entire day watching TV and drinking beer. It was great! Set-expressions: on the whole, taken as a whole, the whole nine yards in its entirety The expression "whole life" considers one's life to be a single unit that has not been subdivided. An "entire life" means all the parts (years or experiences) of a life. In this case either could be used. Though they have similar meanings, "whole" is a little less formal and a bit more common than "entire".

No difference.

As far as most English speakers are concerned, there is no real difference between “whole” and “entire” except that “entire” sounds a bit more formal.