To escape (from)
In a sentence like this: "It's something nobody can escape" can you just leave it like this or you should add "from" - "nobody can escape from"?

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Both are possible, though the meaning may be slightly different, depending on what the object is.

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Thanks GregS! Su.ki has written below there's a slight difference between the two. I wonder if this difference is just stylistic or the meaning actually changes a bit.

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If you extend the example:
The feeling of hopelessness is something nobody can escape.
or
Nobody can escape from the feeling of hopelessness.
Same meaning, essentially.