The difference between cooperate, co-operate and coperate What's the difference between cooperate, co-operate and coperate?? Thanks a lot!!

About "life just got to him" What's the meaning of "Life just got to him"? And how to use this phrase? Thx!!

About "point of fact " Will "in point of fact" be used without "in" in spoken language? And what's the meaning of "point of fact"? Is its meaning different from "in point of fact"?

What's the meaning of “on a bigger note”? In the TV series Felicity season1 episode4, Felicity said to her roommate: "On a bigger note, how could you tell Elena about me and Noel?" Before this, Felicity has blamed her roommate because she had put her underwear into Felicity's fridge. This means her roommate annoyed Felicity again. Thanks a lot!!