This song is very big in gym/weightlifting culture. I used to powerlift to it but the ending of the song where he goes into a pseudo-freudian breakdown is a bit irritating. I think it's a song about mental illness (madness), particularly that arising from parental abuse. Mother is used in context of mother f**ker which is an insult: You mother get up come on get down with the sickness You fu**er get up come on get down with the sickness.