Can I use these interchangeably?

before doing something etc.

Since when do you ask for my permission?
Since when have you been asking for my permission?

Question

Can I use these interchangeably?

before doing something etc.

Since when do you ask for my permission?
Since when have you been asking for my permission?

Answer

You can say:
Since when do you ask for my permission?
Since when did you ask for my permission?
Since when have you asked for my permission?

Use simple tenses because asking permission is not a continuous action.