First, let's consider the man-made or mechanical form:
Wikipedia indicates:
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"A guidance system is a virtual or physical device, or a group of devices implementing a guidance process used for controlling the movement of a ship, aircraft, missile, rocket, satellite, or any other moving object. Guidance is the process of calculating the changes in position, velocity, attitude, and/or rotation rates of a moving object required to follow a certain trajectory and/or attitude profile based on information about the object's state of motion.[1][2][3]
A guidance system is usually part of a Guidance, navigation and control system, whereas navigation refers to the systems necessary to calculate the current position and orientation based on sensor data like those from Compasses, GPS receivers, Loran-C, Star trackers, Inertial measurement units, Altimeters, etc. The output of the navigation system, the navigation solution, is an input for the guidance system, among others like the environmental conditions (wind, water, temperature, etc.) and the vehicle's characteristics (i.e. mass, control system availability, control systems correlation to vector change, etc.). In general, the guidance system computes the instructions for the control system, which comprises the object's actuators (e.g, thrusters, reaction wheels, body flaps, etc.), which are capable to manipulate the flight path and orientation of the object without direct or continuous human control."----read more @
http://en.wikipedia.org/wiki/Guidance_system
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Next, we can consider "inertial guidance" in living organisms: