Hi Jessica, Homie tends to be more American slang and not widely used in England so you would be unlikely to hear it used here. As I understand it though it does tend to be used mainly between males, perhaps "homegirl" would be more appropriate for females, however as with homie this is not used in England. To correct your question; I have a question. Can I use "homie" if I'm talking to a girl, or woman? What I mean is, I know I can call a close friend "homie". I just want to know if I can call one of my girlfriends homie? Thanks a lot. I know my English is not the best but I'd appreciate it if besides answering my question, you could correct what I wrote.

This is a word used mostly by black people living in cities, or rap singers, or people immitating rap singers that is its origin so it is very slangy. It means "homeboy" , which means "friend". It is not offensive but if you say it people might laugh at you, because only people from certain places say it. "I was hanging with my homies at my crib." means : I was relaxing with my friends at my house (or any place that person is currently living) but I dont know if you can use it for girls

It's an American term. It's informal but of course you can use it although when you're referring to a friend that's a girl you would say "Homegirl". Homie is usually used for males :)