A, B, C and D IS... can be used if you treat A, B, C and D as a singular entity if they are related. For example, "Haste and impatience makes errors"

Be careful to keep your tense the same throughout, Yi. “About 13.5 billion years ago, matter, energy, time and space come (not 'come', but CAME) into being in what is known as the Big Bang.”

Hello. It is because you cannot count them. For example, your little sister spilled water on the table. ...Would you say, "my sister spilled water..." or "my sister spilled waterS..."?? The answer is "water", because you cannot count water. Unless you have a countable object (something that you can count in numbers) to compliment water, then it would be okay. For example, "my sister dropped the WATER BOTTLES..." (<-- good). Another example is "sugar". You're cooking.....and you need sugar. --> "I need sugar in this recipe." (<--good......it's "sugar" because you "CANNOT" count the sugar.) "I need SUGAR CUBES in this recipe." (<-- good.......it's "sugar cubeS" because you CAN count the cubes.)

因為當matter指物質, “energy”(能量), “time”(時間) and “space(空間)時，皆屬不可數名詞(Uncountable Nouns)，所以在此一律用單數。 當然如果這些字是別的意思時，則有可能使用複數，所以得依照字義來判斷。 使用複數的例子： it is a matter of ...... I put all my energies to...... How many times......in ancient times.......I had a hard time....... It is a great space. 希望對你有所幫助嚕

I’m afraid those words are usually not countable as used in that context. If we need to count them, we use measure words such as kilograms and liters. On the other hand, those same words can be countable when they have different meanings. “Matter” is countable in a sentence like “there is a matter that we should discuss”. “Space” is countable in a sentence like “there are thousands of spaces in that parking garage.” “Time” is not countable if it means 时间 (although it can be counted in years, hours, etc.), but it is countable in the sense of “occasion” (like 次).