Your original question was whether you should choose 'Best regards' or 'Regards.'
Within personal, friendly correspondence I suppose that we could assert that there's really "no difference." When considering business exchanges, however, Forbes, a well-known, global company with a focus on business, consulted experts:
"All of that said, here is a list of common and not-so-common email sign-offs, with commentary and notes from the experts.
Best – This is the most ubiquitous; it’s totally safe. I recommend it highly and so do the experts.
My best – A little stilted. Etiquette consultant Lett likes it.
All best – Harmless.
All the best – This works too.
Best wishes –Seems too much like a greeting card but it’s not bad.
Bests – I know people who like this but I find it fussy. Why do you need the extra “s?”
Best regards – More formal than the ubiquitous “Best.” I use this when I want a note of formality.
Regards – Fine, anodyne, helpfully brief. I use this.
Rgds – I used to use this but stopped, because it’s trying too hard to be abbreviated. Why not type three more letters? OK if you’re sending it from your phone.
Warm regards – I like this for a personal email to someone you don’t know very well, or a business email that is meant as a thank-you.
Warmest regards – As good as Warm regards, with a touch of added heat.
Warmest – I use this often for personal emails, especially if I’m close to someone but not in regular touch."